I recently joined Giving What We Can, an organization whose members pledge "to give 10% of their income to the most effective charities they can find." Guided by GiveWell's careful research, I've begun by donating $1500 to Stop TB -- an action that can be estimated to save two adult lives. (I'll follow up with a similar donation next month.) I live pretty frugally, so won't especially miss the money, and it's neat to be able to make such a significant impact so easily. Hopefully the spread of GWWC will encourage more people to seriously consider this!
One encouraging sign is that a growing number of academics are now members of GWWC, including Toby Ord, Peter Singer, Thomas Pogge, Nir Eyal, and Adam Swift. I'm told that Derek Parfit and Janet Radcliffe Richards have said they'll join, and Julian Savulescu has endorsed the organization here. There are many grad student members too, especially philosophy grads. Anyway, as more people join, and tell their friends about it, this should help promote a 'culture of giving' that will make charitable giving easier and more salient as a live option for many people.
[I don't know about others, but a major barrier for my past self was just that I thought of charitable giving as something cool that "other people" did. (I certainly couldn't have seen myself jumping right in by giving away 10% of my income.) This naturally caused some cognitive dissonance given my consequentialist ideals, but it seemed difficult to overcome my habitual inertia and modify what I conceived of as "the kinds of things that I do." For anyone else in this position, I'd recommend a little experimentation: just try donating a smaller amount (say $100) to an effective charity, and then see how you subsequently feel about it on reflection. Assuming you feel pretty good about acting on your values in this way, you may eventually find your self-conception developing in a more philanthropic direction. And once you start to think of yourself as the kind of person who really wants to make the world a better place, you'll hopefully find the thought of signing on to GWWC's 10% pledge positively appealing.]
Anyway, do think about it! And if 10% sounds a bit excessive for you to begin with, don't be put off -- every little bit helps, after all. Peter Singer offers a much more modest pledge (as low as 1%, and just for the one year) on his The Life You Can Save website. That'd be a great place to start. [Update: See also GWWC's new Give More Tomorrow pledge option.]
Finally, once you've pledged to give, take care to give effectively. GWWC points out that some developing world health programs are "up to 10,000 times as effective as others"! I strongly recommend GiveWell: they start from such pessimistic assumptions that you can be confident that the few charities they recommend really will make effective use of your donation. I also recommend supporting meta-charities such as GiveWell itself. (You can kill two birds with one stone by donating money to GiveWell to re-grant, or by donating to a recommended charity through GiveWell's website, so that they can keep track of their influence and use these numbers as an incentive for more charities to submit to their evaluation process.)