Clark asks: What are the fundamental issues you are most interested in and see as very important? I've offered such a list before, but here's an updated (though no doubt similarly incomplete) list:
(1) Is value purely additive? Is the value of a whole (life, society) simply the sum of the intrinsic values of the parts (moments, individual lives), or do the relations between the parts also have non-instrumental import? See, e.g., my post distinguishing Welfare and Contributory Value. Related questions ask whether more pain is thereby worse, and whether duplication may be discounted. [Update: see here for my new paper on this topic, which should give a better sense of what these questions are getting at.]
(2) How should we understand Consciousness and Time? In particular, how radically could objective and experienced time diverge? (If we accept that the brain can represent time using something other than time itself, is there any necessary connection here at all? How exactly do temporally extended or 'smeared' representations work?)
(3) How objective is rationality? Is there any genuine sense in which one "ought" to believe as the 'equal weight' and 'automatic adjustment' views claim?
(4) Does rationality require impartiality? Are there agent-(time-)relative values/reasons?
(5) What's the relation between Rationality and Reflective Endorsement? If certain biases are good to have, is there some less-strict but still genuinely normative framework (perhaps what's "reasonable", rather than strictly "rational") for human beings to live by? How coherent will this be?
(6) Is Rational Pluralism possible, or is there one ideally rational belief (and desire?) set -- one objectively privileged 'prior'?
(7) Are there substantive facts about identities and essences, or are the 'base facts' of the world purely qualitative? (In other words: Kripke or Lewis?)
(8) What are the truth-makers for a priori philosophical truths? Is some form of meta-philosophical Constructivism defensible? Or some alternative view?
What 'big questions' most interest you, dear reader?